A study by Japanese experts has found that frequent overeating, especially a very large dinner, leads to a total caloric intake far exceeding the body's needs. This causes excess body fat and increased blood lipids, leading to atherosclerosis of the brain's arteries. It also causes a significant increase in a substance called "fibroblast growth factor." This factor promotes the proliferation of capillary endothelial cells and fat cells, accelerating the development of atherosclerosis. If overeating continues long-term, the increase of this growth factor in the brain can lead to the hardening of cerebral blood vessels, reducing the supply of oxygen and nutrients to the brain. This results in a decline in memory, premature aging of the brain, and dullness of intellect.